Hsu Lab

Biological Sciences · Virginia Tech

Publications

Peer-reviewed research

A complete and current list is on Google Scholar. If you are unable to access any of these papers, email Bryan for a copy.

2026

Prophage-encoding engineered bacteria enable prophylactic lytic phage therapy for enteric infection in miceRA Bataglioli, H Baaziz, HF Avalos, L Smith, ZR Baker, RJ Makhlouf, D da Silva Barreira, H Kaur, T Southard and BB Hsu
Nature Microbiology 10.1038/s41564-026-02484-3

Bacteriophage-mediated cell lysis externalizes a metabolically valuable nutrient to broadly modulate bacterial communitiesD da Silva Barreira, HM Poole, RA Bataglioli, and BB Hsu
The ISME Journal 20, wrag160 10.1093/ismejo/wrag160

Sustained in situ protein production and release in the mammalian gut by an engineered bacteriophageZR Baker, Y Zhang, H Zhang, HC Franklin, P Serpa, T Southard, L Li, BB Hsu
Nature Biotechnology 44, 90-99 10.1038/s41587-025-02570-7

2025

A bacteriophage-conditional mouse model reveals the impact of phages within a conventionally colonized gut microbiotaHC Franklin, R Makhlouf, AD Ha, R Bataglioli, Z Baker, S Murphy, H Jirsa, J Heuler, T Southard, FO Aylward, and BB Hsu
Cell Host & Microbe 33, 745-758.e6 10.1016/j.chom.2025.04.002

2024

A naturally derived biomaterial formulation for improved menstrual careRA Bataglioli, H Kaur, J Muller, E Geddes, C Champine, BB Hsu
Matter 7, 2941-2958 10.1016/j.matt.2024.06.028

Bacterial resistance to temperate phage is influenced by the frequency of lysogenic establishmentH Baaziz, R Makhlouf, M McClelland, BB Hsu
iScience 27, 109595 10.1016/j.isci.2024.109595

2023

Characterization of prophages in bacterial genomes from the honey bee (Apis mellifera) gut microbiomeEK Bueren, AR Weinheimer, FO Aylward, BB Hsu, DC Haak, LK Belden
PeerJ 11, e15383 10.7717/peerj.15383

The pros, cons, and unknowns of prophages in the mammalian gutBB Hsu
BioEssays 45, 2300096 10.1002/bies.202300096

2022

Rehabilitation of a misbehaving microbiome: phages for the remodeling of bacterial composition and functionH Baaziz, ZR Baker, HC Franklin, BB Hsu
iScience 25, 104146 10.1016/j.isci.2022.104146

2021

Towards the Characterization and Engineering of Bacteriophages in the Gut MicrobiomeBB Hsu
mSystems 6 (4) 10.1128/msystems.00735-21

2020

In situ reprogramming of gut bacteria by oral deliveryBB Hsu*, IN Plant, L Lyon, FM Anastassacos, JC Way, and PA Silver
Nature Communications 11, 5030 10.1038/s41467-020-18614-2 (*Corresponding)

Stable Neutralization of a Virulence Factor in Bacteria Using Temperate Phage in the Mammalian GutBB Hsu*, JC Way, PA Silver*
mSystems 5 (1) 10.1128/msystems.00013-20 (*Co-corresponding)

2019

Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse ModelBB Hsu, TE Gibson, V Yeliseyev, Q Liu, L Lyon, L Bry, PA Silver, GK Gerber
Cell Host & Microbe 25, 803-814.e5 10.1016/j.chom.2019.05.001

Engineered Interspecies Amino Acid Cross-Feeding Increases Population Evenness in a Synthetic Bacterial ConsortiumM Ziesack, TE Gibson, JKW Oliver, AM Schumaker, BB Hsu, DT Riglar, TW Giessen, NV DiBenedetto, L Bry, JC Way, PA Silver, GK Gerber
mSystems 4, e00352-19 10.1128/msystems.00352-19

2016

Rapid and efficient sprayed multilayer films for controlled drug deliveryBB Hsu*, SR Hagerman*, and PT Hammond
Journal of Applied Polymer Science 133 (25) 10.1002/app.43563 (*Co-first)

2015

Biodegradable nano-films for capture and non-invasive release of circulating tumor cellsW Li, E Reategui, MH Park, S Castleberry, JZ Deng, B Hsu, S Mayner, A Jensen, M Toner, SL Stott, PT Hammond
Biomaterials 65, 93-102 10.1016/j.biomaterials.2015.06.036

Clotting Mimicry from Robust Hemostatic Bandages Based on Self-Assembling PeptidesBB Hsu, W Conway, CM Tschabrunn, M Mehta, M Perez, S Zhang, and PT Hammond
ACS Nano 9, 9394-9406 10.1021/acsnano.5b02374

Multifunctional Self-Assembled Films for Rapid Hemostat and Sustained Anti-infective DeliveryBB Hsu, SR Hagerman, K Jamieson, SA Castleberry, W Wang, E Holler, JY Ljubimova, and PT Hammond
ACS Biomaterials Science & Engineering 1, 148-156 10.1021/ab500050m

2014

Effects of Gas Feed Ratios and Sequence on Ethylene Hydrogenation on Powder Pt Catalyst Studied by Sum Frequency Generation and Mass SpectrometryA Ghosh, BB Hsu, SM Dougal, M Afeworki, PA Stevens, MS Yeganeh
ACS Catalysis 4, 1964-1971 10.1021/cs500109b

Multilayer Films Assembled from Naturally-Derived Materials for Controlled Protein ReleaseBB Hsu, SR Hagerman, K Jamieson, J Veselinovic, N O’Neill, E Holler, JY Ljubimova, PT Hammond
Biomacromolecules 15, 2049-2057 10.1021/bm5001839

Multimonth controlled small molecule release from biodegradable thin filmsBB Hsu, M Park, SR Hagerman, PT Hammond
PNAS 111, 12175-12180 10.1073/pnas.1323829111

Ordered and Kinetically Discrete Sequential Protein Release from Biodegradable Thin FilmsBB Hsu, K Jamieson, SR Hagerman, E Holler, JY Ljubimova, and PT Hammond
Angewandte Chemie International Edition 53, 8093-8098 10.1002/anie.201403702

2012

Hydrophobic polycationic coatings that inhibit biofilms and support bone healing during infectionTP Schaer, S Stewart, BB Hsu, AM Klibanov
Biomaterials 33, 1245-1254 10.1016/j.biomaterials.2011.10.038

2011

An antimicrobial polycationic sand filter for water disinfectionA Onnis-Hayden, BB Hsu, AM Klibanov, and A Gu
Water Science and Technology 63, 1997-2003 10.2166/wst.2011.440

Hydrophobic polycationic coatings disinfect poliovirus and rotavirus solutionsAM Larson, BB Hsu, D Rautaray, J Haldar, JZ Chen, and AM Klibanov
Biotechnology and Bioengineering 108, 720-723 10.1002/bit.22967

Light-Activated Covalent Coating of Cotton with Bactericidal Hydrophobic PolycationsBB Hsu, and AM Klibanov
Biomacromolecules 12, 6-9 10.1021/bm100934c

Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycationsBB Hsu, SY Wong, PT Hammond, JZ Chen, and AM Klibanov
PNAS 108, 61-66 10.1073/pnas.1017012108

On structural damage incurred by bacteria upon exposure to hydrophobic polycationic coatingsBB Hsu, J Ouyang, SY Wong, PT Hammond, and AM Klibanov
Biotechnology Letters 33, 411-416 10.1007/s10529-010-0419-1

2008

Influence of Particle Size on Reaction Selectivity in Cyclohexene Hydrogenation and Dehydrogenation over Silica-Supported Monodisperse Pt ParticlesRM Rioux, BB Hsu, ME Grass, H Song, and GA Somorjai
Catalysis Letters 126, 10-19 10.1007/s10562-008-9637-8

2007

Interfacial and Chemical Properties of Pt/TiO2, Pd/TiO2, and Pt/GaN Catalytic Nanodiodes Influencing Hot Electron FlowJY Park, JR Renzas, BB Hsu, and GA Somorjai
Journal of Physical Chemistry C 111, 15331-15336 10.1021/jp074562h